Two cases of cutaneous lymphadenoma: a histological and immunohistological study
10.3760/cma.j.issn.0412-4030.2009.07.001
- VernacularTitle:皮肤淋巴腺瘤二例组织学及免疫组化研究
- Author:
Liuqing CHEN
;
Hongying CHEN
;
Ling MA
;
Bilin DONG
;
Yihua JIANG
;
Liang ZHANG
;
Weizhen WANG
;
Yiqun DUAN
- Publication Type:Journal Article
- Keywords:
Cutaneous lymphadenoma;
Histology,immunohistological
- From:
Chinese Journal of Dermatology
2009;42(7):445-447
- CountryChina
- Language:Chinese
-
Abstract:
The histological and immunohistological features of two cases of cutaneous lymphadenoma was studied. A single, erythematous nodule with smooth surface developed on the face of both patients. The lesion slowly progressed. Histology revealed irregular epithelial lobules in the dermis which showed a peripheral palisaded border of basaioid-like cells as well as a center composed of clear cells. Some epithelial lobules and surrounding stroma were infiltrated by numerous small lymphocytes. Immunohistological study showed that the lymphocytic infiltration was predominantly composed of T cells (CD3 positive) along with a small number of B cells (CD20 positive). Within epithelial lobules and surrounded stroma, there were numerous dendritic cells that were positive for S-100 and CDia but negative for cytokeratin 7, cytokeratin 20 or carcino-embryonic antigen. In the center of epithelial lobules in one case, a few cells positive for epithe-lial membrane antigen and CD30 was observed. The diagnosis of cutaneous lymphadenoma was made according to the pathological and immunohistochemical findings, and the infiltration was predominated by CD3-positive lymphocytes in this uncommon epithelial neoplasm.
