The expression and significance of nerve growth factor and its receptors in pancreatic ductal adenocarcinoma
10.3760/cma.j.issn.0578-1426.2009.07.010
- VernacularTitle:神经生长因子及其受体在人胰腺导管癌组织中的表达
- Author:
Lingxin MENG
;
Zhaojun DING
;
Xiping CHEN
;
Lisheng FEI
;
Yuhua CHI
;
Zhigang ZHAO
;
Xiaofang WANG
;
Xishan HAO
- Publication Type:Journal Article
- Keywords:
Nerve growth factor;
Pancreatic neoplasms;
Nerve invasion;
Pain
- From:
Chinese Journal of Internal Medicine
2009;48(7):562-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate nerve growth factor (β-NGF) and its receptors expression in human pancreatic ductal adenocarcinoma. Methods Expression and distribution of β-NGF, tyrosine kinase A (TrKA) and P75NGFR were detected in operation tissue specimens of pancreatic ductal adenocarcinoma with immunohistochemistry and real-time PCR. Relations of β-NGF and its receptors with clinicalpathological characters, especially nerve invasion were analyzed. Results β-NGF and TrKA expression are higher in pancreatic adenocarcinoma than normal pancreas, and the differences are significant (P < 0. 01). Β-NGF and TrKA expression are associated with the differentiation grades(DG), lymphatic node metastasis, nerve invasion and surgical pathological stages. Poorer of DG and later stages, more expression of β-NGF and TrKA. Β-NGF and TrKA expression have positive correlations. Β-NGF, TrKA and P75NGFR mRNA expression have significantly increased 3.84,4. 23 and 2. 41 times than normal tissues by real-time PCR, respectively. Conclusions β-NGF and TrKA might play potential rules in carcinogenesis for pancreatic cancer,have affinity with clinicopathological characters of pancreatic cancer. Β-NGF and TrKA may have mutual effect in signal transduction leading to perineural invasion of pancreatic carcinoma.
