Effects of CosA plus Prednisone in the treatment of primary sjogren syndrome combined with thrombocytopenia
10.3760/cma.j.issn.1671-7368.2009.07.022
- VernacularTitle:泼尼松联合环孢素A治疗干燥综合征合并血小板减少的临床观察
- Author:
Yan WANG
;
Baoliang LV
;
Shaoting WANG
;
Yan WANG
;
Hong YANG
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Sjogren's syndrome;
Thrombocytopenia
- From:
Chinese Journal of General Practitioners
2009;8(7):486-488
- CountryChina
- Language:Chinese
-
Abstract:
Thirty patients with confirmed primary sjogren syndrome and thrombocytopenia during January 2002 and December 2007 were investigated.All the participants received 0.5 mg·kg-1·d-1 Prednisone and 100 ms/d CosA for 1 year.Clinical symptoms and the levels of white blood eell.platelet count,erythrocyte sedimentation rate,liver function,immunoglobin,and rheumatoid factors were recored before and after the treatment.After one-year follow.up,platelet count was elevated(t=11.4179,P< 0.01).There was no significant change in erythrocyte sedimentation rate.The concentrations of immunoglobin and rheumatoid factors were significantly decreased at 1 year(t=5.4222,P<0.01;t= 9.2857.P<0.01).Prednisone plus CosA could effectively treat primary sjOgren syndrome combined with thrombocytopenia and result in fewer side effects.
