The clinical,neuroimaging and electrophysiological presentations in 62 cases with multiple system atrophy
10.3760/cma.j.issn.1006-7876.2009.07.011
- VernacularTitle:多系统萎缩患者的临床、影像及电生理分析
- Author:
Feng QIU
;
Xiaokun QI
;
Sheng YAO
;
Liping LI
;
Jianguo LIU
- Publication Type:Journal Article
- Keywords:
Multiple system atrophy;
Magnetic resonance imaging;
Electromyography;
Electrophysiology
- From:
Chinese Journal of Neurology
2009;42(7):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical,neuroimaging and electrophysiology features of 62 patients with multiple system atrophy(MSA).Methods Sixty-two cases with diagnosis of probable MSA were recruited in a retrospective studied.Clinical,neuroimage and external anal sphincter electromyography (EAS-EMG)data was retrospectively analyzed.Results In 62 cases(44 male and 18 female),the onset age was between 37 and 76.Among them,29 cases(46.8 % )were MSA-A,with orthostatie hypotension as the main clinical manifestation;24 cases(38.7 % )were MSA-C,with cerebellar ataxia ag the main chnical manifestation;9 cases(14.5 % )were MSA-P,with extrapyramidal symptoms as the main clinical manifestation.MRI showed that main lesion of MSA-A was in the cerebellum:that of MSA-C was in the cerebellum,pons and medulla;and that of MSA-P was in the putamen.Fifty-one cases did EAS-EMG and 46 cases showed neurogenie impairments.Nineteen cases were initially misdiagnosed with other diseases.Conclusions MSA is easy to be omitted or misdiagnosed at early stage.The diagnostie rate of MSA can be increased by the combination of clinical expressions,neuroimage,EAS-EMG and other necessary examinations.
