Quantitative detecetion of HBsAg concentrations by chemiluminescent microparticle immunoassay and its relationships with anti-HBs,HBeAg and HBV DNA

VernacularTitle:化学发光微粒子免疫分析技术测定HBsAg浓度及与抗-HBs、HBeAg和HBV DNA的关系
Author: Wenhu CHEN ; Bin LOU
Publication Type:Journal Article
Keywords: Hepatitis B surface antigens; Chemiluminescent microparticle immunoassay; Quantitative detection
From: Chinese Journal of Clinical Infectious Diseases 2009;2(3):143-146
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance of quantitative detection of serum HBsAg.Methods Serum concentrations of HBsAg were detected by chemiluminescent microparticle immunoassay in 7612 hospitalized non-hepatitis patients.The distribution of HBsAg positive patients and the relationship of HBsAg concentration with serum anti.HBs.HBeAg and HBV DNA were analyzed.Results The HBsAg positive rate was 11.4%(870/7612)in this series.The serum HBsAg ranged from 0.08 U/mL to 125 000 U/mL with a median of 932.28 U/mL.No significant difference of HBsAg concentrations between male and female patients was observed(Z=-0.366,P＞0.05).1.There were negative correlation of HBsAg concentration with the age of patients(r=-0.370,P＜0.01),and positive correlations of HBsAg with HBeAg(r=0.654,P＜0.01)and HBV DNA levels(r=0.765,P＜0.01).Conclusion The quantitative determination of seFum HBsAg may be useful in estimating the hepatitis B viral replication and clearance.