Variety and significance of Intermedin on hypoxic pulmonary arterial hypertension in rats
10.3760/cma.j.issn.1008-6706.2009.06.031
- VernacularTitle:中介素在低氧性肺动脉高压大鼠中的变化和意义
- Author:
Xiuqing HUO
;
Zhonghe YU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Intermedin;
hypoxia;
pulmonary hypertension
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(6):1015-1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and compare the changes of Intermedin's contents in plasma and bron-choalveolar lavage fluid (BALF) in rats with hypoxic pulmonary hypertension. Methods male Wistar rats were ran-domly divided into control group and 1,2 and 3 weeks hypoxia group. Intermedin's contents in plasma and bronchoal-veolar lavage fluid were measured by radioimmunoassay. Results Intermedin's contents in plasma and bronchoalveo-lar lavage fluid were markedly increaseded compared with control group. Meanwhile transformational trend is consist-ent between plasma and bronchoalveolar lavage. Conclusions Intermedin's contents in plasma and bronchoalveolar lavage increase ,which shows that there is protection and moderation to hypoxic pulmonary hypertension.
