The role of postmastectomy radiotherapy in breast cancer patients with T1-T2 and one to three positive axillary nodes
10.3760/cma.j.issn.1004-4221.2009.04.291
- VernacularTitle:T1～T2期伴1～3个腋窝淋巴结转移乳腺癌患者改良根治术后放疗的作用
- Author:
Shulian WANG
;
Zihao YU
;
Yexiong LI
;
Yuan TANG
;
Shunan QI
;
Jianzhong CAO
;
Wenqing WANG
;
Tao LI
;
Jing JIN
;
Weihu WANG
;
Yongwen SONG
;
Yueping LIU
;
Xinfan LIU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms/surgery;
Breast neoplasms/radiotherapy;
Breast neoplasms/chemotherapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2009;18(4):291-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the outcomes and the role of radiotherapy in breast cancer pa-tients with T1-T2 and one to three positive axillary nodes treated with modified radical mastectomy, and to investigate the prognostic factors for loco - regional recurrence in patients without radiotherapy . Methods Three hundred and seventy breast cancer patients with T1-T2 and one to three positive axillary lymph nodes treated with mastectomy and axillary dissection were retrospectively analyzed. Kaplan-Meier method was used to calculate the overall survival (OS) and loco-regional recurrence-free survival (LRFS) rates. The Logrank test was used for the comparison of the survival curves of patients with or without radiotherapy. Univariate analyses of potential prognostic variables for LRFS were performed. Results The 5-year OS and LRFS rates were 85.4% and 91%. Radiotherapy significantly improved the 5-year LRFS rate ( 100% vs. 89.5% ;x2 = 5.17, P=0.023). However, there was no significant difference in overall survival rate between patients with and without radiotherapy. In univariate analyses, T stage, the number of positive axillary nodes, C-erbB-2 and PR status were the significant predictive factors for LRFS. Conclusions For breast cancer pa-tients with T1-T2. and one to three positive axillary nodes, radiotherapy improves the LRFS, but not OS. T stage, the number of positive axillary nodes, C-erbB-2 and PR status are predictive factors for loco-regional recurrence in patients without radiotherapy.
