Experiment study on MR diffusion weighted imaging in rabbit models of lymphadenopathy:comparison between inflammatory and metastatic lymph node

VernacularTitle:扩散加权成像鉴别兔炎性及转移性淋巴结肿大的实验研究
Author: Bing WU ; Jing LIU ; Xiaoying WANG
Publication Type:Journal Article
Keywords: Lvmph nodes: Diffusion magetic resonance imaing: Models.animal
From: Chinese Journal of Radiology 2009;43(7):759-761
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of MR DWI in comparing inflammatory with metastastic lymph node in animal models of lymph disease.Methods Eighteen rabbits with benign lymphadenopathy and 9 rabbits with malignant lymphadenopathy underwent routine MRI and DWI examination.Independent-samples t test was used to compare the sizes and apparent diffusion coefficient (ADC) values between the two groups.Results Thirty-four inflammatory lymph nodes and 18 metastastic lymph nodes were observed .The size of lymph nodes was (8.14±2.79) and (6.29±1.48) mm in the benign and malignant groups, respectively.There was no significant statistical difference between the sizes of the two groups (t=2.624, P 0.05).Mean ADC value of lymph nodes was (1.19±0.31)×10-3mm2/s and (1.31±0.27)×10-3mm2/s in the benign and malignant groups, respectively.There was no significant statistical difference between the ADC values of benign and malignant lymph nodes (t=1.449,P 0.05).Conclusion DWI sequence can be used to show lymphadenopathy, but the ADC value is insufficient to differentiate benign lymph nodes from malignant lymphadenopathy.