Expression and clinical significance of ezrin in breast carcinomas
10.3760/cma.j.issn.1008-6315.2009.07.010
- VernacularTitle:ezrin在乳腺癌中的表达及其临床意义
- Author:
Wenguang LI
;
Yanni ZHANG
;
Hai YAN
;
Li LING
;
Jingwei LI
;
Haiying JIANG
;
Yenfang LI
- Publication Type:Journal Article
- Keywords:
Ezrin;
Breast carcinoma;
Immunohistochemistry;
Prognosis
- From:
Clinical Medicine of China
2009;25(7):699-701
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of ezrin in breast carcinoma. Methods Immunohistuchemieal staining(S-P) was used to detect the expression of ezrin in 63 cases of breast car-cinoma samples. Results Among these 63 samples,the total expression rates of ezrin were 55.56% (35/63). With the increasing of axillary lymph nodes metastasis and clinical staging,the rates of expressing of ezrin elevated (P<0.05),which was remarkably lower in patients whose disease-free survival(DFS) was > 5 years,or those whose DFS≤5 years or died within five years(P<0.05) ,but the expression of ezrin was not correlated with tumor size,age and menopausal status (P>0.05). Conclusion The expression of ezrin may contribute to prognostic e-valuation for breast carcinoma.
