Relationship between human papillomavirns and cervical carcinoma
10.3760/cma.j.issn.1671-7368.2009.04.009
- VernacularTitle:人乳头状瘤病毒与宫颈癌生物学行为的相关性研究
- Author:
Bin YU
;
Peizhen XU
;
Qiuwei WANG
;
Yishan DONG
;
Bin ZHANG
- Publication Type:Journal Article
- Keywords:
Papillomavirus infections;
DNA,viral;
Nucleic acid hybridization;
Uterine cervical neoplasms
- From:
Chinese Journal of General Practitioners
2009;8(4):238-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between high-risk human papillomavirus (HPV) DNA and biological behavior of cervical carcinoma. Methods Sixty-six patients of cervical carcinoma with cytological examinations and 103 patients of cervical carcinoma followed-up after surgical operation were selected for high-risk HPV DNA test with second-generation hybrid capture technique (HC2 Ⅱ). Results ①HPV DNA was positive in 62 and negative in four of 66 patients of cervical carcinoma with an overall prevalence of 94%. ②There was no significant difference in positive HPV DNA of patients with cervical carcinoma between their varied clinical stages and pathologic grades. But, HPV positivity and HPV DNA load in patients with myometrial invasion were higher than those in patients without invasion (P < 0. 05).③ HPV DNA conversed to negative in 99 of 103 patients (96%) with cervical carcinoma after surgical operation from positivity before operation. Conclusions High-risk HPV infection may correlate with angiogenesis, invasion and metastasis of cervical carcinoma and HC2 Ⅱ can be used as an effective method to detect HPV DNA.
