Simultaneous dosage of metronidazole and clotrimazole in Vaginal tablets by method of HPLC
- Author:
Thai Duy Thin
- Publication Type:Journal Article
- Keywords:
Medication
- MeSH:
Vaginal Diseases;
Chromatography, High Pressure Liquid;
Metronidazole;
Clotrimazole
- From:Pharmaceutical Journal
2005;0(8):27-29
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
An HPLC method was proposed to determine simultaneously metronidazole and clotrimazole in tablets with the chromatographic conditions as follow: Column: Lichrosorb RP 8 (250x4mm; 5Mm). UV detector at 215 nm. Mobile phase: Methanol: dipotasium hydrogen phosphate 0.025M (2:1). Flow rate: 1ml/min. The experimental results proved that the proposed HPLC method had a high accuracy 0.49 - 1.53%, maybe applied regularly in experimental centers
