Study on the diagnostic value of adiponectin/leptin ratio in metabolic syndrome in elderly men
10.3760/cma.j.issn.0254-9026.2009.07.013
- VernacularTitle:脂联素瘦素比值在老年男性代谢综合征患者中的诊断价值
- Author:
Ting TAO
;
Feika LI
;
Beibei SHEN
;
Yongju ZHAO
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Leptin;
Metabolic syndrome XDOI: 10. 3760/cma. j. issn. 0254-9026. 2009.07.013
- From:
Chinese Journal of Geriatrics
2009;28(7):567-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between adiponectin/leptin(A/L) ratio and metabolic syndrome diagnosis in elderly men. Methods A total of 256 elderly men (≥60 years) were enrolled and divided into metabolic syndrome group(n= 109) and non metabolic syndrome group (n= 147). Serum levels of adiponectin and leptin were measured by radioimmunoassay (RIA) and the A/L ratio was calculated. Metabolic syndrome diagnosis is based on the definition provided by China Diabetes Society (CDS) in 2004. Results (1) In metabolic syndrome group versus non metabolic syndrome group, the serum levels of leptin and adiponectin were (10. 3±7.0) vs (6.8±4.9)μg/L and(7.8±5.6)g/L vs (9.5±5.9)g/L, and A/L ratio was 0. 94±0. 78 vs 2.15±2.13 respectively. (2) A/L ratio was positively correlated with high density lipoprotein cholesterol (HDL-C) and negatively correlated with body mass index (BMI), triacylglycerol (TG) and serum uric acid(P< 0. 001). (3) The higher value of A/L ratio, the lower possibility of metabolic syndrome. When the A/L ratio was more than 5, the incidence of metabolic syndrome was decreased to O(X2 =34. 891 ,P< 0.001). (4) The more components of metabolic abnormality, the lower value of A/L ratio(F= 10. 876,P<0. 001). Conclusions The A/L ratio may be useful in evaluating the extent of metabolic disorder and diagnosing metabolic syndrome in elderly men.
