Clinical research of low dose dexamethasone pretreatment regimen in prevention of hypersensitive reaction related to docetaxel in elderly tumor patients
10.3760/cma.j.issn.0254-9026.2009.07.017
- VernacularTitle:低剂量地塞米松预处理方案防治老年人多西紫杉醇过敏反应的临床研究
- Author:
Mingjun ZHANG
;
Zhendong CHEN
;
Yueyin PAN
;
Jiqing HAO
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Antineoplastic agents;
Anaphylaxis
- From:
Chinese Journal of Geriatrics
2009;28(7):580-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of low-dose dexamethasone pretreatment regimen in prevention of hypersensitive reaction (HR) related to docetaxel in elderly tumor patients. Methods According to the order for admission and the ratio of 3:2, 91 elderly patients with docetaxel weekly therapy were randomly divided into two groups: experimental group and control group. All patients aged from 65 to 82 years with a median age of 68 years old. There were 54 patients in the experimental group and 37 patients in the control group. In the experimental group, patients received oral dexamethasone 4. 5 mg once daily on 1 day before treatment, the day of treatment and continuing for 3 days after treatment, while patients received 8 mg twice daily in the control group. All patients were scored according to MCIRS by the physician. The side effects were evaluated by NCI-CTCAE3.0. Results Four cases in the experimental group (7.4 %) and three cases in the control group (8. 1%) occurred HR, and there was no significant statistical difference (P=1. 000). Conclusions The low dose dexamethasone is efficient and safe compared with the conventional dose dexamethasone, and there is no significant difference in HR incidence between two groups.
