Feasibility study of Shuyisha as hemostasis and repair material for liver wound

VernacularTitle:术益纱作为肝创伤止血修复材料的可行性研究
Author: Jinwei GAO ; Wanshun LIU ; Baoqin HAN ; Jing CHANG ; Yan YANG ; Chenwei FU
Publication Type:Journal Article
Keywords: Hemolysis rate; Cytotoxicity; Hemostasis; Shuyisha
From: Chinese Journal of Trauma 2009;25(7):658-662
CountryChina
Language:Chinese
Abstract: Objective To discuss the feasibility of Shuyisha as hemostasis and repair material for liver wound. Methods Hemolysis rate, acute toxicity and eytotoxicity of Shuyisha were measured. A hemorrhage model was established by making an open wound (5 mm× 3 nun ×2 mm) on the left liver lobe of mice. Hemostasis was performed with Shuyisha in experimental group and with Surgicel in control group, when the hemostatic time and total blood loss (TBL) were accurately recorded and regular macro-scopic and histological observation carried out. Results The hemolysis rate of Shuyisha was 2.33%, with maximum tolerance does of over 0.48 g/kg and the eytotoxicity at zero. The hemostatie time of Shuy-isha was (5.00 ±0.00) s, with total blood loss of (0.88±0.18) g/kg, better than Surgicel (P< 0.05). Shuyisha was degraded completely within 14 days, with the wound healed within 21 days in ex-perimental group, much better than Surgieel. Conclusions The hemolysis rate, acute toxicity and cy-totoxicity of Shuyisha are up to the requirement of biomedical materials. Shuyisha has effective hemosta-sis, which may be related to its molecular structure and adhesion.