Toxic megacolon induced by primary ulcerative colitis

VernacularTitle:初发型溃疡性结肠炎致中毒性巨结肠五例分析
Author: Chaowu CHEN ; Zhongcheng HUANG ; Shiying CHENG ; Meilai TANG ; Zhigang XIAO ; Qi LIU
Publication Type:Journal Article
Keywords: Colitis,ulcerative; Megacolon,toxic; Surgical procedures,operative
From: Chinese Journal of General Surgery 2009;24(7):547-549
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical manifestations and treatment for toxic megacolon induced by drastic cathartics inpatients with an unknown history of ulcerative colitis. Methods The clinical data of 5 patients with toxic megacolon induced by ulcerative colitis with initial onset type from June 2003 to October 2008 were analyzed retrospectively. Results In 5 cases, the first symptom was abdominal pain and distention. After taking cathartics, these 5 cases were complicated with toxic megaeolon and 2 cases suffering from intestinal perforation. Four female patients suffered from transient unconsciousness, in which 3 patients were found with cerebral lacunal infarction identified by magnetic field diffusion-weighted imaging. All 5 cases underwent exploration, colectomy and ostomy, one patient died perioperatively, anastomotic fistula and anastomotic constriction developed in one each cases. Conclusions The most common clinical manifestations of toxic megacolon induced by ulcerative colitis are abdominaigia, abdominal distention. Emergency therapeutic strategy consists of partial culectomy and ostomy.