Change of estrogen in patients with pulmonary artery hypertension secondary to congenital heart disease
10.3760/cma.j.issn.1673-4904.2009.21.005
- VernacularTitle:先天性心脏病肺动脉高压患者血中雌激素含量变化与机制
- Author:
Hongmei XUE
;
Xianyang ZHU
;
Duanzhen ZHANG
;
Jing MENG
- Publication Type:Journal Article
- Keywords:
Heart defects,congenital;
Hypertension,pulmonary;
Estrogens
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(21):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of estrogen in patients with pulmonary artery hypertension (PAH) secondary to congenital heart disease (CHD). Methods A total of 144 patients with CHD including 36 patients with normal pulmonary arterial pressure as control group, and 108 with PAH were investigated as PAH group. Their pulmonary artery pressure was measured by right heart catheterization and the serum concentrations of estradiol, progesterone, prolactin and follicle stimulating hormone (FSH) were detected by chemiluminescence immunoassay. Results The serum concentrations of estradiol, progesterone, prolactin and FSH in PAH group were significantly higher than those in control group (P<0.05). Multiple regression analysis showed that the concentrations of estradiol, progesterone and prolactin were not correlated with the site of shunt but significantly correlated with physiologic factor including sex, age and menstrual cycle, and the level of mean pulmonary arterial pressure. The correlation coefficient of mean pulmonary arterial pressure to them was 0.607,0.531 and 0.518 respectively. The concentration of FSH was positively correlated with the prolactin and estradiol with a related coefficient of 0.917 (P=0.012) and 0.759 (P= 0.000). Conclusion The estrogen plays an important role in modification of the pulmonary arterial pressure in patients with CHD and PAH.
