The effect of new-onset diabetes after renal transplantation on arterial stiffness
10.3760/cma.j.issn.0254-1785.2009.07.007
- VernacularTitle:肾移植术后新发糖尿病的危险因素及其对动脉僵硬度的影响
- Author:
Hang LIU
;
Yi SHI
;
Zhongyang SHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Kidney transplantation;
Arteriosclerosis
- From:
Chinese Journal of Organ Transplantation
2009;30(7):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factor for new-onset diabetes after transplantation (NODAT) and the relationship between NODAT and arterial stiffness. Methods Oral glucose tolerance test (OGTT) was performed on 195 patients with renal transplantation. The degree of arterial stiffness, which was determined by brachial ankle pulse wave velocity (baPWV), anklebrachial blood pressure index (ABPI) and intima-media thickness (IMT) of the carotid artery, was evaluated. Results Twenty-nine patients diagnosed as NODAT had significantly higher fasting plasma glucose before transplantation, blood pressure and incidence of hepatitis C virus (HCV) infection than in patients without NODAT. Multivariate regression analysis revealed that the risk factor of NODAT was fasting plasma glucose pre-transplantation, HCV infection and systolic blood pressure.The independent determinant of the advanced arterial stiffness on NODAT was the statement of hypertension and age. Conclusions High fasting plasma glucose prior to transplantation, HCV infection and high blood pressure are risk factors for NODAT in patients after renal transplantation.Strict control of blood pressure is the key way to prevent the NODAT and atherosclerosis.
