The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome
10.3760/cma.j.issn.1008-6315.2009.07.006
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征及合并高血压患者8-异前列腺素F2α与C-反应蛋白的变化
- Author:
Ping LI
;
Fen PING
;
Jiejing SUN
;
Shuzhi HAN
;
Chong LI
;
Qi LI
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea-hypopnea syndrome;
Essential hypertension;
8-iso-PGF2α;
C-re-active protein;
Oxidative stress;
Inflammation
- From:
Clinical Medicine of China
2009;25(7):686-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.
