Association of interleukin-23 receptor gene rs1343151 single nucleotide polymorphism with ankylosing spondylitis

VernacularTitle:白细胞介素-23R单核苷酸多态性rs1343151与强直性脊柱炎的相关性研究
Author: Songsen SU ; Ling LIN ; Zhen CHEN ; Mingxuan ZHOU ; Xiaoqing CHEN ; Peizeng YANG
Publication Type:Journal Article
Keywords: lnterleukin; Spondylitis,ankylosing; Alleles
From: Chinese Journal of Rheumatology 2009;13(7):477-479
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between interleukin-23 receptor (IL-23R) gene rs1343151 single nucleotide polymorphism and ankylosing spondylitis (AS) in Chinese Han patients. Methods The genotypes of IL-23R SNP was detected in 104 Chinese AS patients and 95 ethnically matched blood donors by TaqMan probe assays. The allele and genotype frequencies and risk factors of AS were analyzed by Chi-square test in both groups. Results The rs 1343151 genotypes in AS patients consisted of homozygote C/C (90.4%),C/T (9.6%), while The rs1343151 genotypes in the controls were. composed of C/C (91.6%), C/T (8.4%). No significant difference was found in the distribution of rs1343151 genotypes between these two groups (x2=0.086, P>0.05). The frequency of rs1343151 allele in AS patients was also not significantly increased when compared with the control group (x2 =0.082,P>0.05). Conclusion There may be no association between the IL-23R gene rs1343151 SNP and ankylosing spondylitis in Chinese Hart population.