Expression and significance of β-catenin and peroxisome proliferator-activated receptor-γ in hepatocellular carcinoma
10.3760/cma.j.issn.1008-6315.2009.07.030
- VernacularTitle:β-连环蛋白和过氧化物酶体增殖物激活受体γ在肝癌中的表达及意义
- Author:
Kun HE
;
Zemin HU
;
Zaiping ZHOU
;
Hong CHEN
;
Huizhou DENG
- Publication Type:Journal Article
- Keywords:
Hepatocellular neoplasm;
β-catenin;
Peroxisome proliferator-activated receptor-γ;
Im-munohistochemistry
- From:
Clinical Medicine of China
2009;25(7):746-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of β-catenin and peroxisome prolifera-tot-activated receptor-γ,(PPARγ) in bepatocellular carcinoma. Methods Tissue microarrays were established to detect β-catenin and PPARγ expression in 49 cases of hepatocellular carcinoma,49 cases of adjacent nontumoral liv-er tissue and 6 cases of normal liver tissue. The relationships between PPARγ and β-catenin as well as between PPARγ and clinicopathological parameters were observed. Results The aberrant expression rate of β-catenin was 69.39%,48.98 % and 0 respectively (P=0.001). The positive expression rate of PPARγ was 51.02%,30.61% and 0 respectively (P=0.016). Clinicopathological analysis revealed that the increase of PPARγ expression was not associated with age,tumor size,serum alpha fetoprotein (AFP) levels,tumor embolus of portal vein or inferior vena cava,and HBsAg infection(χ2=0.214,3.201,0.046,3.201,P>0.05 for each),but correlated with differentiation grades(χ2=4.693,P<0.05). Aberrant expression of β-catenin was associated with PPARγ expression(χ2= 5.130,P<0.05). Conclusion Aberrant expression of β-catenin may involve in the liver carcinogenesis. The high expression of PPARγ in hepatocellular carcinoma is significantly correlated with the clinicopathological characteris-tics. Detection of PPARγ is valuable for diagnosing hepatocellular carcinoma,and evaluating malignancy extent and prognosis.
