Antitumor mechanisum of a new antitumor drug-Cpd 5
10.3760/cma.j.issn.1673-422X.2009.07.004
- VernacularTitle:Cpd5的抗肿瘤作用机制
- Author:
Li CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Apoptosis;
Cpd5
- From:
Journal of International Oncology
2009;36(7):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Cpd 5 (2-(2-mercaptcethanol)-3-methyl-1,4-naphthoquinone,Compound 5) is a potent growth inhibitor and apoptesis inducer in several tumor cell lines in vivo and in vitro. The mechanisms of cell in-hibition are partialy elucidated. Cpd 5 arrests cell cycle progression, affects the expression of some related genes by inhibiting PTP (protein tyrosine photophatase), specially Cdc25, and inducts the prolonged phosphorylation of ERK (extracellular signal-regulated kinase), then results in cell growth inhibition. Cpd 5 inhibits CREB (cAMP response element-binding protein)and phesphorlation of pp90RSK, which inhibits expression of genes mediated by cAMP response element and cell growth. Furthemore, Cpd 5 activats caspaso passway and induces apoptosis of the cells. Cpd 5 is a promising novel anticancer drug.
