The relationship between TMPRSS2-Ets fusion gene and prostate cancer
10.3760/cma.j.issn.1673-422X.2009.07.020
- VernacularTitle:跨膜丝氨酸蛋白酶2-Ets融合基因与前列腺癌的关系
- Author:
Yanfeng BAI
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Gene fusion;
In situ hybridization,fluorescence;
Serine endopepti-dases;
Ets
- From:
Journal of International Oncology
2009;36(7):535-539
- CountryChina
- Language:Chinese
-
Abstract:
A unique fusion between the TMPRSS2 gene and the Ets genes ERG,ETV1、ETV4 or ETV5 has been described in prostate cancer, TMPRSS2-ERG is the most high frequency of all. Until now more than 20 kinds of TMPRSS2- ERG hybrid transcripts are found, and they encode 9 kinds of proteins. Deletion is the main mechanism of fusion. Fusion gene can be used to make a diagnosis of prostate cancer , direct clinical medication , then fusion type, fusion number and transcriptive type are also associated with prognosis of dis-ease. So, besides of serum PSA, Gleason score, TMPRSS2- ERG is expected to be another important predicator of prognosis.
