Pathogenesis in reversible posterior leukoencephalopathy syndrome
10.3760/cma.j.issn.1673-4165.2009.06.008
- VernacularTitle:可逆性后部白质脑病综合征的发病机制
- Author:
Rui LI
;
Xueqiang HU
- Publication Type:Journal Article
- Keywords:
posterior leukoencephalopatby syndrome;
etiology;
pathology;
magnetic resonance imaging
- From:
International Journal of Cerebrovascular Diseases
2009;17(6):444-447
- CountryChina
- Language:Chinese
-
Abstract:
Reversible posterior leukoencephalopathy syndrome (RPLS) is a cliniconeuroradiological entity mainly characterized by the rapidly progressive increase in blood pressure, headache, vomiting, conscious disturbance and seizure. Neuroimaging showed symmetrical reversible white matter edema in bilateral cerebral hemispheres, particularly in posterior brain.Clinical symptoms and neuroimaging changes can be recovered completely with timely and correct treatment. The two major hypotheses about the pathogenesis of RPLS-cerebral vasospasm and cerebrovascular hyperperfusion-have been in dispute. At preseut, most researchers still agree that the latter is the main cause of cerebral edema. This article expounds the new viewpoints of its pathogenesis and the above two major hypotheses in recent years from the characterizations of etiology, pathology and imaging of RPLS.
