Restoration of segmental bone defects by using chitosan-coated pressed calcium sulfate pellet com-bined with rhBMP-2
10.3760/cma.j.issn.1001-8050.2009.07.210
- VernacularTitle:壳聚糖包衣加压硫酸钙片复合重组人骨形态发生蛋白-2修复兔节段性骨缺损
- Author:
Xu CUI
;
Boxun ZHANG
- Publication Type:Journal Article
- Keywords:
Calcium sulfate;
Radius;
Osteogenesis
- From:
Chinese Journal of Trauma
2009;25(7):648-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of calcium sulfate pellets made by different methods in repair of segmental radial defect of rabbits. Methods Eighty white New Zealand rabbits were sub-jected to defects of middle part of the left radial bone and divided into four groups according to repair ma-terials: control group (Group A, implanted with no artificial bone substitute), uncoated pressed calcium sulfate pellets (Group B), coated pressed calcium sulfate pellets (Group C) and coated pressed calcium sulfate pellets combined with rhBMP-2 (Group D). Histologic examination and biological test were done at 4, 8 and 12 weeks after operation. The data were processed with mono-factor variance analysis. Re-sults New bone formation was found on the defected bone in Group D and Group C, with better in Group D. The bone strength test showed that the anti-bending strength was (39.6±1.7) % in Group C and (47.5±2.1) % in Group D, which were higher than (21.3±2.7) % in Group A and (23.6±3.3) % in Group B, with higher anti-bending strength in Group D than that in Group C (F = 125.3 ,P <0.01). Conclusions For restoration of segmental bone defects, chitosan-coated pressed calcium sulfate pellet shows relatively high density and slightly slow resorption, which closely coincides with the growth rate of new bone. The coated pellet combined with rhBMP-2 can enhance its osteogeneais in restoring segmental Done defects.
