Relationship of hypoxia-inducible factor-1 with the occurrence and development of tumor
10.3760/cma.j.issn.1673-4203.2009.07.021
- VernacularTitle:低氧诱导因子-1与肿瘤发生发展的关系
- Author:
Bo SUN
;
Yan GU
- Publication Type:Journal Article
- Keywords:
hypoxia-inducible factor-I;
chemokin factor;
migration inhibitory factor;
spot tumor micro-enviroment
- From:
International Journal of Surgery
2009;36(7):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-I is the critical factor existed in mammal and human cells which plays an important role in maintaining the oxygen balance. Many hypoxia-responding genes can be activated by H1F-1. So, the relationship between HIF-land matrix matalloproteinases/stromal-derived factor-I/special CXC chemokin receptor/angiogenesis related factors is the hot spot in research of the tumor invasion and me-tastasis.
