Clinical Study on Zoledronic Acid Combined With Radiotherapy in the Treatment of Cancer Patients with Bone Metastasis

VernacularTitle:唑来膦酸联合放疗治疗骨转移癌的临床研究
Author: Zhifei WEN ; Lianxing LIN ; Shunhou CAI ; Hecheng HUANG
Publication Type:Journal Article
Keywords: Bone neoplasms; Drug therapy,combination; Radiotherapy; Zoledronic acid
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(7):1244-1245
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy of zoledronic acid combined with radiotherapy for bone meta-static cancer. Methods 71 cases with bone metastatic cancer were randomly divided into observation group (40 ca-ses) and control group (31 cases). The observation group was treated with zoledronic acid, 4 mg intravenously and local radiotherapy. The control group was treatd by radiotherapy alone. Results Pain relief was noted in 90% pa-tients in the observation group and 83.9% in the control group, respectively. The statistical difference was not signif-icant(P > 0.05). After the treatment had finished 3 months pain alleviation situation:Pain relief was noted in 87.5% patients in the observation group and 67.7% in the control group, respectively. The difference between the two groups was significant(χ2 =4.09, P =0.043). No serious radiotherapy and serious adverse drug reactions was found. Conclusion Zoledronic acid combined with radiotherapy was superior to radiotherapy alone for metastatic cancer bone pain relief, analgesic effect maintain a longer time.