Role of COX-2-independent targets of celecoxib and related compounds on cancer prevention and treatment

VernacularTitle:塞来昔布非环氧化酶-2依赖性抗肿瘤作用靶点的研究进展
Author: Jian GAO ; Jiansheng LI
Publication Type:Journal Article
Keywords: coxibs; celecoxib; cancer
From: International Journal of Surgery 2009;36(8):541-544
CountryChina
Language:Chinese
Abstract: We reviewed the role of COX-2 independent targets of celecoxib and related compounds in cancer prevention and treatment. Direct non-COX-2 targets of celecoxib might be protein-dependent kinase 1 (PDK-1),Ca+ ATPase and carbonic anhydrase (CA), and so on; all of which are inhibited by celecoxib and are the main components in various pathways. Inhibition of these proteins leads to the induction of apoptnsis, the inhibition of cell cycle progression, angiogenesis, and metastasis, which are the main mechanisms by which celecoxib exerts its anticarcinogenic activity.