Lipoprotein-associated phospholipase A2 and ischemic stroke
10.3760/cma.j.issn.1673-4165.2009.06.012
- VernacularTitle:脂蛋白相关磷脂酶A2与缺血性卒中
- Author:
Lei WANG
;
Zhaohu CHU
- Publication Type:Journal Article
- Keywords:
lipoprotein-associated phospholipase A2;
atherosclerosis;
polymorphism,genetic
- From:
International Journal of Cerebrovascular Diseases
2009;17(6):463-466
- CountryChina
- Language:Chinese
-
Abstract:
The human plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) is secreted, by the mature macrophages and lymphocytes, which predominantly binds to low-density lipoprotein. Studies in recent years have demonstrated that Lp-PLA2 plays an important role in the process of atherogenesis. Its gene polymorphisms are associated with the occurrence of ischemic stroke, and its specific inhibitor has anti-atherogenic effects. Lp-PLA2 may be a novel independent risk factor and a therapeutic target for ischemic stroke.
