The clinical value of serum amyloid A in acute exacerbations of chronic obstructive pulmonary disease

VernacularTitle:血清淀粉样物质A在慢性阻塞性肺疾病急性加重中的临床意义
Author: Shunlin LIU ; Minhua SHI
Publication Type:Journal Article
Keywords: Pulmonary disease,chronic obstructive; Serum amyloid A
From: Chinese Journal of Postgraduates of Medicine 2009;32(22):18-20
CountryChina
Language:Chinese
Abstract: Objective To investigate the diagnostic value of serum amyloid A(SAA)in diagnosing acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods A total of 86 patients with AECOPD and 46 patients with stable COPD were recruited.SAA determined with ELISA was compared between AECOPD patients and stable COPD patients.The changes of SAA,WBC,the percentage of neutrophils and C-reactive protein (CRP) of AECOPD patients Was compared before and immediately after the last treatment procedure.Results The SAA levels in AECOPD patients were higher than those in stable COPD patients [(182.33±50.12)mg/L vs (6.24±3.05)mg/L,P<0.05].The change of SAA was more evident than that of serum WBC and the percentage of neutrophils before and after the treatment procedure. SAA was more sensitive than CRP in diagnosing lung function severity of AECOPD patients.Conclusion SAA has great diagnostic value in AECOPD diagnosis and evaluation of lung function severity.