Clinical significance and possible mechanism of DJ-1 expression in tumors
10.3760/cma.j.issn.1673-422X.2009.07.005
- VernacularTitle:DJ-1在肿瘤中表达的临床意义及作用的可能机制
- Author:
Xiangyi HE
- Publication Type:Journal Article
- Keywords:
Neoplasms;
DJ- 1
- From:
Journal of International Oncology
2009;36(7):494-496
- CountryChina
- Language:Chinese
-
Abstract:
DJ-1, ubiquitously expressed in various human tissues, is a multi-functional protein that plays roles in tumors, Parkinson' s disease, breeding and apoptosis. Over- expression of DJ-1 which is identified as a novel oncogene has been reported in several cancer cells. The underlying mechanisms include the anti-oxi-dative stress reaction, down-regulating phosphatase and tensin homolog deleted on chromosome 10 (PTEN) pathway and up-regulating Androgen pathway. However, there are also some evidences show low-expression of DJ-1 in tumor cells.
