The dual effects of interleukin-18 in cancer
10.3760/cma.j.issn.1673-422X.2009.07.008
- VernacularTitle:白细胞介素18的双重作用与肿瘤
- Author:
Xuewei DING
- Publication Type:Journal Article
- Keywords:
Interleukin- 18;
Tumor escape;
Thl cells/Th2 cells immune response
- From:
Journal of International Oncology
2009;36(7):501-504
- CountryChina
- Language:Chinese
-
Abstract:
IL-18 was discovered as a proinflammatoty cytokine,stimulates natural killer and T cells and enhances Th1/Th2 immune response, and plays a central role in inflammation and immune response.. Immune-stimulating effects of IL-18 as a adjuvent agent against cancer,have antineoplastic properi-ties. However, Higher expression or secretion level of IL- 18 is detected in the blood of the majority of cancer pa-tients with poor prongnosis. IL-18 has also been associated with cancer progression and immune escape,is able to induce angiogenesis, metastasis. The dual effects of IL-18 in cancer need to be investigated further.
