The relationship between CD44 and the resistance to antineoplastic agents of breast neoplasms
10.3760/cma.j.jssn.1673-422X.2009.07.015
- VernacularTitle:CD44与抗乳腺癌药物耐药性的关系
- Author:
Jue WANG
- Publication Type:Journal Article
- Keywords:
Antigens,CD44;
Breast neoplasms;
Drug resistance,neoplasm
- From:
Journal of International Oncology
2009;36(7):521-524
- CountryChina
- Language:Chinese
-
Abstract:
The cell adhesion molecule CD44 antigen correlates with the antineoplastic agents resistance of breast neoplasms closely. Its high expression can enhance the invasion of the breast neoplasms. CD44 mole-cule can affect the expression of the TGF-β of breast neoplasm cells to induce the resistance to tamoxifen. The influence on erbB-2 cell signal pathway result in the resistance to the trastuzumab. CD44 can strengthen the re-sistance to anthracene nucleus by inducing expression of protein MRP2 and inhibiting the topoismerase. The modulation of survivn and multidrug resistance gene intensifies the resistance to paclitaxel.
