Over-expressions of macrophage migration inhibitor factor and cyclin D1 correlates with clinical pathologic characteristics of pancreatic carcinoma and it significance
10.3760/cma.j.issn.1673-422X.2009.07.025
- VernacularTitle:巨噬细胞移动抑制因子和细胞周期蛋白D1的表达与胰腺肿瘤临床病理特征的关系及意义
- Author:
Jie ZHAO
;
Jingtang XIA
;
Wen LI
;
Longjuan ZHANG
;
Hua WANG
;
Zhaofeng WU
;
Yuan TAN
;
Cheng XU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Macrophage migration-inhibitor factor;
Cyclin D1;
Neoplasm me-tastasis
- From:
Journal of International Oncology
2009;36(7):550-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of macrophage migration inhibitor factor (MiF) and cyclinD1 in pancreatic carcinoma and their relationships with clinical pathology characteristics. Methods The expression of MIF and eyclinD1 in 89 carcinoma and 5 normal pancreatic tissues was detected with immunohis-tochemistry methods, and the relationships among MIF and cyclinD1 expression and clinicopathological factors were studied. Results The overexpression of MIF and cyclinD1 was found in 88.8%, and 50. 6% of pancre-atic carcinoma tissues respectively. The overexpression of MIF had a significant correlation with Ⅰ,Ⅱ,Ⅲ,Ⅳ tumor stage (69. 2%, 94. 7%, 96. 4%, 100%, P <0.05), while the positive expression rate of cyclinD1 only had a significant correlation with tumor stages Ⅲ,Ⅳ (33. 3%, 68. 8%, P <0. 05). Both of the two proteins had a correlative tendency with pathological grade and lymph node metastasis. The different expression of MIF between pancreatic carcinoma with and without liver metastasis had no statistical significance, (100% ,85.9%, P >0. 05)while there was a statistically significant difference about cyclinD1 (66. 7% ,46. 5% ,P <0. 05). A significant positive correlation was also found between MIF and cyclinD1 (P < 0. 05). Conclusion The ex-pression of MIF and CyclinD1 was higher in pancreatic cancer tissues than in normal tissue, and they may be associated with the malignant stage, tumor differentiation, local lymph node and liver metastasis of this tumor.
