Changes of growth hormone,brain natriuretic peptide and adrenomedullin in congestive heart failure
10.3760/cma.j.issn.1008-6706.2009.07.023
- VernacularTitle:心力衰竭患者血浆生长激素、脑利钠肽和肾上腺髓质素的变化
- Author:
Yun ZENG
;
Jianzhong DING
;
Hongyu ZHOU
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Growth hormone;
Brain natriuretic peptide;
Adrenomedullin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(7):1188-1189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of growth hormone(GH), brain natriuretic peptide(BNP) and adrenomedullin(ADM) in congestive heart failure patients. Methods The blood samples were obtained from 60 pa-tients with congestive heart failure(CHF) and 30 patients without CHF,and their serum/plasma levels of GH,BNP and ADM were measured by enzyme-labeled immunosorbentassay(ELISA) and radioimmunoassay. At the same time all the patients received colorful Doppler ultrasonocardio-gram to determine left ventricular end-dilation diameter (LVED) and left ventrieular ejection fraction(LVEF). Results The levels of BNP and GH in heart failure group were[(0.83±1.06) μg/L,(115.31±191.16) ng/L] higher than eontrol group[(0.15±0.42) μg/L, (33.51±49.85) ng/L] (t = 2.689, t = 2.765, P < 0.01); The efficiency and total efficiency in heart failure group was (39.7% ,76.5%) higher than control group (32.3%, 61.3%) (t = 1.894, P > 0.05, t = 2.265, P < 0.05); The sensitivities and specificities of BNP were 89.3% and 63.0%; The sensitivities and specificities of GH were 85.7% and 59.3%; The BNP combined with GH were 75.0% and 74.0%. Condusion The combination of GH and BNP is better than application alone in the diagnosis of CHF.
