Clinical effects of tirofiban intra-coronary artary inject on patients with ST segment elevation myocardial infarction no-reflow and acute thrombosis after emergency intra-coronary artary stenting

VernacularTitle:替罗非班治疗冠脉支架植入术后无复流及急性血栓形成的临床观察
Author: Junhua SUN ; Yiqiang YUAN ; Huailin LIU ; Li YU ; Yingxian GUO ; Ruimin WANG ; Yun SUN
Publication Type:Journal Article
Keywords: myocardial infarction; Stenting no-reflow; Thrombosis; Tirofiban
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(7):1241-1242
CountryChina
Language:Chinese
Abstract: ObjectiveTo evaluate the efficacy and safety of tirofiban in treatment of ST segment elevation acute myocardial infarction(STEAMI) no-reflow and acute thrombosis after emergency percutaneous coronary intervention(PCI). MethodsForty patients which were made definite diagnosis of STEAMI were intra-coronary artary injection fortirofiban after emergency PCI stenting occured no-reflow and acute thrombosis. First,the dose of 0.4μg·kg-1·min-1 was given from intra--coronary artary injection of tirofiban within three minutes, after 30min the dose were given 0.1μg·kg-1·min-1 for 48 hours. ResultsThe no re-flow and acute thrombosis was completely disappeared within five minutes,at the time,side effect with in one week was not observed. ConclusionsTirofiban treatment by direct injection in coronary arteries combined with emergency PCI, can increase the repeffusion rate of infarction related vessel in AMI patients,and improve TIMI reflow. This reperfusion method was effective and safe.