Expression of Survivin and PTEN in gastric cancer and its clinic significance
- VernacularTitle:Survivin、PTEN在胃癌中的表达及临床意义
- Author:
Xudong LIANG
;
Huanshe DU
;
Xiaofeng SHI
- Publication Type:Journal Article
- Keywords:
Microtuhle-associated proteins/BI;
Tumor suppressor proteios/BI;
Stomach neoplasms/ME
- From:
Journal of Chinese Physician
2009;11(7):901-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship among Survivin, PTEN and the occurrence, development, soakage and prog-nesis of gastric cancer. Methods The in-situ hybrization technique, immunochemistry and TUNEL method were used to detect the expres-sion of survivin mRNA, PTEN protein and apoptotic cell. Results The positive rate of survivin expression in gastric cancer was obvious higher than that in para-cancer tissue(P <0.01). Moreover, survivin expression rate in advanced clinical stage and low differentiation gastric cancer degree.was higher, compared with para-cancer tissue (P <0.01, P <0.05). The positive rate of PTEN expression in gas-tric cancer was obvious lower than that in pars-cancer tissue (P <0.01). The positive rate of PTEN expression in advanced clinical stage and low differentiation degree of tissue in gastric cancer was lower (P < 0.01). Furthermore, survivin and apoptesis indexes manifested negative relationship in gastric cancer(r =-0.861, P < 0.01), While PTEN and apoptosis indexes manifested positive relationship (r = 0.832, P < 0.01). Conclusions Survivin could be used as a novel marker to detect gastric cancer. PTEN gene lost function, which maybe promote the origin, growth, soakage and metastasis of gastric cancer.
