Cardiac protection effect of fructose-1, 6-diphosphate in patients with primary bone cancer treating with chemotherapy
10.3760/cma.j.issn.1008-6706.2009.07.048
- VernacularTitle:1,6二磷酸果糖对恶性骨肿瘤化疗患者心脏保护作用的研究
- Author:
Liping CUI
;
Qicai BAI
;
Chun LIU
;
Jie YU
- Publication Type:Journal Article
- Keywords:
Bone nenoplasms;
Drug therapy;
fructose-1,6-diphosphate;
electrocardiogram
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(7):1226-1227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cardiac protection effect of venous fructose-1,6-diphosphate in pa-tients with primary bone malignant tumors. Methods 178 patients received 9 times of chemotherapy were randomly divided into non-cardiac protective therapy group (A group)and cardiac protective therapy group(B group). The car-diac toxicity was reflected by abnormal electrocardiographic changes. The abnormal electrocardiographic changes were compared in two groups. Results Abnormal electrocardiographic changes were significantly decreased in B group eompared with A group (30 vs 81 ,P <.05). Conclusion The cardiac protective medicine fructose-1,6-diphosphate efficiently decreased the cardiac toxicity in patients with primary bone malignant tumors treating with chemotherapy.
