The expression of COX-2, VEGF, MMP-2 and P-glucoprotein in carcinoma of stomach and its significance
- VernacularTitle:胃癌组织中COX-2与VEGF、MMP-2、P-糖蛋白的表达及意义
- Author:
Lin TIAN
;
Hong YANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/ME;
Prostaglandin-endoperioxide synthase/BI;
Gelatinase A/BI;
Vascular endothelial growthfaetors/BI;
P-glycoprotein/BI
- From:
Journal of Chinese Physician
2009;11(7):917-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of COX-2, VEGF, MMP-2 and P-g]ycoprotein in carcinoma of stomach and its significance. Method The expressions of COX-2, VEGF and P-glycoprotein inside and beside the tumor tissues of 57 cases carcinoma of stomach were detected with immunohistochemistry method. Result The expressions of COX-2, VEGF, MMP-2 and P-glyeoprotein inside the tumor tissues were significantly higher than that beside the tumor(χ2 = 5.29,5.37,5.62,4.87 ; P < 0.05). The expressions of COX-2, VEGF and MMP-2 were different among different carcinoma metastasis (χ2 = 5.97, 6.17,6.09 ; P < 0.05). P-glucoprotein expressions were positive correlated with gastric cancer(rs' = 0.674,0.65,0.67 ; P < 0.05). Conclusion COX-2, VGEF, MMP-2 and P-glyeopretein were some correlated and overexpressed in stomach carcinoma, which may take part in the genesis, development and multi-drug resistance of this cancer.
