Effect of atorvastatin on cyclooxygenase-2 and platelet-activating factor acetylhydrolase and high sensitive C reactive protein in patients with acute coronary syndrome

VernacularTitle:阿托伐他汀对急性冠脉综合征患者外周血炎性因子的影响
Author: Hao TANG ; Yanbing LIANG ; Chengshun ZHAI ; Zhongfu MA
Publication Type:Journal Article
Keywords: Coronary disease; Atorvastatin; Inflamatory factor
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(7):1153-1154
CountryChina
Language:Chinese
Abstract: Objective To study the level of cyclooxygenase-2 (COX-2) and platelet-activating factor acetyl-hydrolase(PAF-AH) and high sensitive C reactive protein(hsCRP) on peripheral blood mononuclear cells in Acute Coronary Syndrome(ACS) patients and the effect of atorvastatin on them and the clinical significance. Methods To measure and compare the content of COX-2,PAF-AH and hsCRP in normal control group and ACS group(before and after treatment). Result The content of COX-2,PAF-AH and hsCRP are significantly different between normal con-trol group and ACS group (before treatment) (P < 0.05), and between ACS group (before treatment) and ACS group (after treatment) too(P < 0.05). Conclusions The inflammatory cytokines COX-2,PAF-AH and haCRP have sig-nificant correlation with the occurance of ACS. Atorvastatin can decrease COX-2 and hsCRP level, and can increase PAF-AH level. So atorvastatin takes an important role in lessening inflamatory reaction level in ACS patients.