The effects of pioglitazone on the expression of ICAM-1 mRNA in the ischemia-reperfusion brain tissues in SD rats
- VernacularTitle:吡格列酮对实验性缺血再灌注大鼠脑组织细胞间黏附分子-1mRNA表达的影响
- Author:
Zhaohui TIAN
;
Zunjing LIU
- Publication Type:Journal Article
- Keywords:
Peroxisome prolifterator-activated receptor γ;
Cerebral ischemia-reperfusion;
Intercellu-lar adhesion molecule-1
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2009;18(7):594-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of peroxisome prolifterator-activated receptor gamma (PPARγ) agonist on the expression of ICAM-1 mRNA in the ischemia-reperfusion brain tissues. Methods Adult male SD rats were randomly divided into: sham-operation + normal saline group (NS,n = 6 ), ischemia-reperfusion tion. The expression of ICAM-1mRNA was measured by RT-PCR at 24 h after ischemia. Results The expression of ICAM-1 mRNA of the low-dose PGZ group (0.571±0.032) and the high-dose PGZ group (0. 396±0.024)were significantly reduced compared with that of the I/R + NS group (0.847±0. 028 ) (P<0.05).Conclusion PPARγ agonists can downregulate the the expression of ICAM-1mRNA in the ischemia brain tissue.
