The expression of placenta growth factor and IL-6 in placentas with different gestational stages and aging placentas
10.3760/cma.j.issn.1008-6315.2009.08.005
- VernacularTitle:胎盘生长因子和白细胞介素-6在正常和老化胎盘组织中的表达及其相关性
- Author:
Yan WANG
;
Lihong ZHANG
- Publication Type:Journal Article
- Keywords:
Placental senescence;
Placenta growth factor;
Interleukin-6
- From:Clinical Medicine of China
2009;25(8):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of placenta growth factor(PLGF) and IL-6 in placentas with different gestational period.Methods Immunohistochemistry method was used to examine the expression of PLGF and IL-6 in placentas of different normal gestational periods and aging placentas.Results The positive expression rates of IL-6 in the first,second and third trimester of pregnancy were 60.0%(6/10),50/O%(3/6),42.9%(6/14)and 88.9%(8/9),and the positive expression rates of PLGF were 60.0%(6/10),100.O%(6/6),100.O%(14/14)and 55.6%(5/9) respectively.PLGF expression intensity was significantly different among the third trimester of pregnancy placentas,the first trimester of pregnancy placentas (X2=18.89) and the aging placentas (X2=20.42)(P<0.01 for each).IL-6 was significantly different between aging placentas and third trimester of pregnancy placentas(X2=9.47,P<0.05).No statistical significance were found on expression of IL-6 and PLGF among the three trimesters and aging groups (X2=0.625,0,0 and 1.41,respectively,P>0.05).Conclusions The decreasing expression of PLGF in aging placenta tissue illustrates that the PLGF synthesis and secretion is decreased by trophoblast cells but IL-6 expression is remarkably increased,which may play an important role in the pathogenesis of placental senescence.
