bFGF and CD105 in gastric carcinoma and its biological behavior
- VernacularTitle:bFGF和CD105在胃癌组织中的表达及其生物学行为
- Author:
Yongqing CAO
;
Qingshan LIU
;
Li ZHANG
;
Hui CHEN
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor 2/Bl;
Vascular cell adhesion molecule-1/BI;
Stomach neoplasms/ME
- From:
Journal of Chinese Physician
2009;11(7):899-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate basic fibroblast grow th factor (bFGF) and CDI05 in gastric carcinoma and its biological be-havior. Methods bFGF, microvessel density (MVD) and stomach cancer cell S phase fraction (SPF) in 60 samples from stomach cancer patients and 20 samples from normal stomach were detected with immunohistochemistry.. Apoptosis in stomach cancer was determined with TUNEL and apoptosis rate (AR) was calculated. Results bFGF protein expression, MVD and SPF in stomach cancer patients were obvi-ously higher than that normal health controls, but AR were lower, bFGF and MVD showed positive relationship with SPF, and negative with AR. Conclusion bFGF possibly increased the MVD state, promoted stomach cancer cell multiplication, suppressed stomach cancer cell ap-optosis.
