Relationship between chronic kidney disease and cerebral small vessel disease in elderly patients
10.3760/cma.j.issn.0254-9025.2009.08.013
- VernacularTitle:老年人慢性肾功能不全与脑小血管病变
- Author:
Hua LI
;
Wenxin ZHAO
;
Suhong REN
;
Fang SUN
;
Lihui DUAN
;
Bin YAN
;
Guoqing ZHOU
- Publication Type:Journal Article
- Keywords:
Renal insufficiency,chronic;
Brain infarction;
Cerebrovaseular disorders;
Leukoencephalopathy,progressive multifocal
- From:
Chinese Journal of Geriatrics
2009;28(8):658-660
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between chronic kidney disease (CKD) and cerebral small vessel disease (SVD) in elderly patients. MethodsOne hundred and fifty-two elderly male CKD patients for experimental group and 158 elderly male for control group were recruited. Demographic data and vascular risk factors were recorded. White matter lesion (WML) was semi-quantitatively assessed by cerebral magnetic resonance imaging (MRI), and lacunar infarction (LI) was also calculated. Results(1) The prevalenees of hypertentsion and diabetes mellitus were higher in elderly CKD patients than those in control group (30. 9% vs. 19.0%, 23.7%vs. 14.6%;both P～0. 05). (2) The percentages of grade 2 and grade 3 WMLs were higher in elderly CKD patients than those in control group (34.9% vs. 24.1%, 25.7% vs. 16.5%;both P<0.05). Prevalence of LI was higher in elderly CKD patients than that in control group (45.4% vs.25.3% ,X2= 13. 70, P<0. 05). The similar Resultswere also obtained except for control subjects with hypertension and diabetes mellitus. (3) The logistic regression analysis showed that age, hypertension and low glomerular filtration rate (GFR) were closely associated with SVD in elderly CKD patients. ConclusionsHypertention and diabetes mellitus are risk factors for CKD in elderly patients. SVD is associated with CKD, and age, hypertension and low GFR may be risk factors for SVD in elderly CKD patients.
