Pharmacokinetics of the antimalarial combination CV8 when given in the manner of a therapeutic dosage regimen in healthy male subjects
- Author:
Trinh Ngoc Hai
- Publication Type:Journal Article
- Keywords:
CV8 malaria
- MeSH:
Malaria;
Antimalarials;
Pharmacokinetics;
Therapeutics;
drugs
- From:Journal of Malaria and parasite diseases Control
2003;3():48-54
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The study was conducted in 2002 for analysis by non-linear regression of compartmental pharmacokinetic model. The results: the plasma-concentration of piperaquine at day 1 and day 3 after CV8 administration were determined. At first stage, only the basic parameters derived from non-compartmental methods were presented and another parameters, models is expected to be presented in later stages. The plasma-concentration of piperaquine of all volunteers were determined with Cmax on day 1 was 1015 nM/L, on day 2 was 1050 nM/L, T1/2 was 30-57 days and Tmax of piperaquine was 3-5 hours after using
