Evaluation of Usefulness of the Panel Test Composed of Malaria Non-specific Tests As a Surrogate Marker.
10.3343/kjlm.2008.28.5.332
- Author:
Yun Hi KANG
1
;
Hwan Sub LIM
;
Hyuk Min LEE
;
Kkot Sil LEE
;
Kyong Min CHOI
Author Information
1. Department of Laboratory Medicine, Kwandong University College of Medicine, Myongji Hospital, Goyang, Korea. holymed@hanmail.net
- Publication Type:Original Article ; Comparative Study ; English Abstract ; Evaluation Studies
- Keywords:
Malaria;
Diagnosis;
Hematology autoanalyzer;
HDL-cholesterol
- MeSH:
Animals;
Autoanalysis;
Biological Markers;
Cholesterol, HDL/*blood;
Diagnosis, Differential;
Hematologic Tests/economics/utilization;
Humans;
Malaria, Falciparum/blood/*diagnosis;
Plasmodium falciparum/isolation & purification;
ROC Curve;
Reagent Kits, Diagnostic;
Sensitivity and Specificity
- From:The Korean Journal of Laboratory Medicine
2008;28(5):332-338
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Although malaria-specific antibody or antigen test is useful for the diagnosis of malaria infection, its cost-effectiveness has to be concerned in the area where malaria prevalence is very low. We created a panel test composed of malaria non-specific parameters, namely hematology autoanalyzer-derived results with or without addition of HDL-cholesterol data, and evaluated its usefulness in comparison with malaria-specific antibody test. METHODS: For 395 patients tested for malaria smear, the hematology parameters such as platelet count, NRBC (%) and VCS (volume, conductivity, scattering) parameters of WBC, and HDL-cholesterol data were analyzed. Statistical significance of each parameter and that of panel test with or without addition of HDL-cholesterol were evaluated. RESULTS: Malaria antibody test showed sensitivity of 97.1% and specificity of 99.1%. Each parameter of platelet count, NRBC (%), D parameter and HDL-cholesterol showed sensitivity of 86.8%, 41.2%, 81.8%, and 70.6%, and specificity of 85.9%, 96.3%, 72.3%, and 81.7%, respectively. Panel test without including HDL-cholesterol showed sensitivity of 91.2% and specificity of 81.6%, and that including HDL-cholesterol showed sensitivity of 91.2% and specificity of 86.2%. CONCLUSIONS: The malaria non-specific panel test composed of hematology autoanalyzer-derived parameters showed relatively good, but slightly lower sensitivity than that of malaria-specific antibody test. It might be used as a screening test for the diagnosis of malaria infection, and addition of HDL cholesterol improved little the usefulness of the panel test.
