Expression and clinical significance of uPA and Cath-D proteins in the diagnosis of cervix carcinoma and cervical intraepithelial neoplasia
10.3760/cma.j.issn.1008-6706.2009.08.044
- VernacularTitle:尿激酶型纤溶酶原激活物和组织蛋白酶D在宫颈鳞癌及其癌前病变中的表达
- Author:
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neopiasia;
Cervical neoplasm;
Urokinase-type plasminogen activator;
Cathepsin D;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(8):1413-1414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression,and biological significance of uPA and Cath-D in early diagnosis of cervix carcinoma and cervical intraepithelial neoplasia.Methods The immunohistochemical SP was used to detect the expression of uPA and Cath-D proteins in 39 CA.ges with cervix carcinoma and 33 ofpatients with CIN cases and 15 cases with normal cervical epithelia.Results Positive rates of uPA and Cath-D in the cervix carcinoma were significantly higher than in the CIN.Positive rates of uPA and Cath-D in the CIN and the cervix carcinoma were significantly higher than in the normal cervical epithelia. The difference had statistical significance( P＜0. 05 ). In the group of CIN Ⅰ/CIN Ⅱ/CINⅢ ,the expression of uPA and Cath-D had significant diffcrence(P ＜0. 05). In the group of highly, moderate and lowly developed tissue, the expression of uPA and Cath-D had significant difference (P＜0. 05). In the group with and without LNM, the expression of uPA and Cath-D had significant difference( P＜0. 01 ).Conclusions uPA and Cath-D may involve in the initiation of CIN, cervix carcinoma, uPA and Cath-D could be used as markers for early diagnosis of cervix carcinoma. It could be helpful for increasing the ratio of earlier diagnosis in the fields of cervix carcinoma.
