Clinical investigation of different blood purification techniques on clearing serum beta2-microglobnlin of chronic renal failure maintenance hemodialysis patients
10.3760/cma.j.issn.1673-4904.2009.24.001
- VernacularTitle:不同血液净化方法对慢性肾衰竭维持性血液透析患者血清β2-微球蛋白的影响
- Author:
Liying MIAO
;
Xiaozhou HE
;
Jinfeng LIU
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
Beta 2-microglobuhn;
Renal dialysis;
High flux dialysis;
Hemodiafiltration;
Resin absorptive devices
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(24):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clear effect of different blood purification techniques on the serum beta2-microglobulin ( β2-MG) of chronic renal failure maintenance hemodialysis patients.Methods Forty chronic renal failure maintenance hemedialysis patients were randomly divided into four groups: hemodialysis group (HD group), high flux dialysis group (HFD group), hemodiafiltration group (H D F group), hemodialysis and absorption group (HD+AP group). The serum β2-MG levels of the four groups were determined and compared before with after the therapy. Results The difference between the serum β2-MG in HD group detected at the first day before and after the therapy was insignificant difference [( 53.49±1.15 ) mg/L vs (49.10±2.31 ) mg/L ] (P > 0.05 ). The difference between the serum β2-MG in HD group detected at the first day before and after the therapy six months later [(55.63±1.30) mg/L] was significant difference (P <0.05). The serum levels at the first day and six months later after the therapy detected in HFD group, HDF group and HD+AP group were significantly decreased compared with those of the first day before the therapy (P < 0.05 ). Furthermore,the serum β2-MG level decreased in HD+AP group was more significant than HFD group and HDF group at six months later (P <0.05). Conclusions Hemodialysis can not clear the serum β2-MG. High flux dialysis, hemodiafiltration and resin absorptive devices associated hemedialysis can clear β2-MG effectively, while resin absorptive devices associated hemodialysis has the better effection after six months.
