The expression and clinical significance of MMP-2 and MMP-7 in colorectal carcinomas
10.3760/cma.j.issn.1008-6315.2009.09.009
- VernacularTitle:基质金属蛋白酶-2、7在结直肠癌中的表达及临床意义
- Author:
Dezhi GUO
;
Baoliang ZHANG
;
Yongqiang ZHENG
;
Xiaojun LI
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Matrix metalloproteinase;
Fluorescent quantitation-reverse transcrip-tion-PCR;
Immunohistochemistry
- From:
Clinical Medicine of China
2009;25(9):920-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of MMP-2 and MMP-7 and their elinieopathologieal significance in eoloreetal carcinomas. Methods The expression of MMP-2 mRNA, MMP-7 mRNA and MMP-2, MMP-7 in 42 samples of eoloreetal carcinomas and its adjacent normal eoloreetal mueosa were examined using fluo-rescence quantitative RT-PCR (FQ-RT-PCR) and immunohistoehemistry. The relationship of their expression with some elinieopathologieal characteristics was analyzed. Results MMP-2 mRNA, MMP-7 mRNA and MMP-2, MMP-7 were significantly over-expressed in eoloreetal carcinomas compared with its adjacent normal eoloreetal mueosa( P < 0.05 ) , and they were positively associated with bowel wall invasion, the regional lymph node metastasis and Dukes stage. The expression of MMP-2 mRNA and MMP-7 mRNA was positively correlated with MMP-2 and MMP-7 in eoloreetal eareinornas. Conclusions MMP-2 and MMP-7 may play a key role in eoloreetal carcinogenesis,tumor in-vasion and metastasis. Examination of combined MMP-2 and MMP-7 expression may have an important significance to judge the malignant degree and biological behavior of human eoloreetal carcinoma and for evaluating the progno-sis.
