The variance of serum IL-18 level and lymphocyte subpopulations in the patients with obese diabetic
10.3760/cma.j.issn.1008-6706.2009.08.003
- VernacularTitle:2型糖尿病并肥胖患者血清白细胞介素-18与淋巴细胞亚群的变化
- Author:
Fuzhen LIU
;
Wenpu CHEN
;
Guixin HUANG
;
Manning LI
;
Tujie SI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus.type 2;
Lymphocyte subsets;
Intertleukin-18
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(8):1349-1350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe on the variance of serum IL-18 level and lymphocyte subpopulations in the patients with obese diabetic(T2DM).Methods The diabetic obese group contained 31 cases,the non-diabetic obese group contained 33 cases,healthy normal body weight group contained 23 cases,the blood glucose(FPG),insulin (FPI),blood total cholesterol(TC),triglyceride(TG),IL-18 and the cell population of lymphocyte subpopulations CD3+and CD4+、CD8+ in peripheral blood were determined,the insulin sensitivity index were calcnlated.Results Compared with the healthy normal body weight group,the blood fat,FPG,FPI,IL-18 of T2DM patients significantly increased,there were significant statistical difference(P ＜ 0.05 or P ＜ 0.01).The ISI significantly decreased(P ＜ 0.01).Compared with the non-diabetic obese group,the blood fat and IL-18 of T2DM patients significantly increased (P＜0.05).Compared with the diabetic obese group,the subpopulations cell population of CD3+、CD4+、CD8+ in the non-diabetic obese group significantly decreased,the ratio of CD4+/CD8+ significantly increased,there were significant statistical difference(P＜0.05 or P＜0.01)in the two groups comparison.Compared with the non-diabetic obese CD4+/CD8+ significantly increased(P＜0.05).Conclusion T2DM patients should prevent the hyperinsulinemia,control blood sugar,reduce insulin resistance,sustain normal lipid metabolism,boost immune function.
