Efficacy of three dimensional conformal radiotherapy combined with concurrent taxotere in treatment of patients with esophageal carcinoma
10.3760/cma.j.issn.1008-6706.2009.08.001
- VernacularTitle:三维适形放疗联合多西他赛同步化疗治疗中晚期食管癌疗效观察
- Author:
Lingxin MENG
;
Zhaojun DING
;
Xiping CHEN
;
Hong ZHANG
;
Yuhua CHI
;
Fengsong WANG
;
Aili ZHANG
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
computer-assisted;
Esophageal neoplasms;
Taxotere
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(8):1345-1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and toxicity of three dimensional confoimal radiotherapy(3D-CRT)concurrent taxotere for patients with esophageal carcinoma.Methods Ninty-six patients with esophageal carcinoma were received 3D-CRT concurrent taxotere,the radiotherapy was carried out by 3D-CRT,to a total dose 95% PTV 66Gy/33f/6.6W.The trial results were evaluated by the clinical curative effect criterion.Results Complete response rate(CR)was 67.7%.Overall response rate(CR+PR)was 89.6%.The local control rates of 1 year and 3 years were 86.5% and 63% ,respectively.The survival rates of 1 year and 3 years were 76.1% and 50.0%,respectively.The main acute toxic effect was radioactive esophagitis.Conclusions 3D-CRT concurrent taxotere could improve the overall response rate and survival rate of esophageal carcinoma.Although it increased the acute toxic effect,the patients could accept the therapy.
